Multimodal LLC

The malaria metabolite HMBPP does not trigger erythrocyte terpene production

The malaria metabolite HMBPP does not trigger erythrocyte terpene production

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.29.225839v1?rss=1 Authors: Miller, J., Odom John, A. R. Abstract: Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, -pinene, is associated with Plasmodium spp. infection in multiple studies and is a known mosquito attractant. However, how malarial infection results in elevated levels of host-associated -pinene remains unclear. One study suggests that erythrocyte exposure to the malarial metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), results in increased levels of -pinene. Here, we establish that endogenous levels of -pinene are present in human erythrocytes, that these levels vary widely by erythrocyte donor, and that -pinene levels are not altered by HMBPP treatment. Copy rights belong to original authors. Visit the link for more info

Release Date:

Share part or all of the audio of this episode